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RESEARCH

RESEARCH FIELDS AND EXPERIENCE

Synthetic Pharmacology

Development of neurotropic drugs to prevent cell death and preserve neuronal pathways by stimulating formation of axons & dendrites

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Design and synthesis of molecules that interface with neuronal cell properties and operate as acceptable pharmacophores for a novel neurotropic (neurite outgrowth inducing) lead compounds.

Development of synthetic agonists that interface with receptors TRPV1 and TRPA1 to treat neuropathic pain

We synthesize agonists that interface with the pain receptor TRPV1. The new molecules contain none of the crucial domains previously believed to be required for this interaction. The overarching value obtained from our inquiry is the novel advancement of the existing TRPV1 activation model. Our findings uncover new potential in the area of pain treatment, providing a novel synthetic platform.

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Complete synthesis of cannabinoids and their structural analogues

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We develop innovative and improved synthesis of a several common cannabinoids: THC, CBG, CBD, THCV, as well as a genuine derivatization of (-)-Δ9- THCV and CBG. We also create synthetic fusions between pharmacologically active market drugs and cannabinoid compounds aiming to discover a new synergetic activity of hybridized substances.

Synthesis of novel psychedelic drugs

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We collaborate with pharmaceutical and medicinal companies whose research profile is the discovery of novel psychedelic-derived therapeutics. The research focuses on the development of innovative, patentable psychedelics as potential drug candidates for treatment of mental health, neurological disorders, and for overall better brain health.

Synthesis of novel antibiotics

We developed first of a kind matrix-like, collective synthesis of a broad spectrum of novel antibacterial compounds, and methods for their preclinical characterizations as potential confluent drugs to target multidrug-resistant pathogens. We study the chemical and biological properties of new molecules, as well as their targets, and modes of action. To achieve these objectives, we employ established synthetic techniques combined with traditional microbiological approaches.

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Synthetic methodology

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Pharmaceutical production line. Vaccine
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Synthesis of multiple targets via selective transformations from a common molecular unit

In the course of our experimental studies, we were able to confirm the hypothesis that the presence of similar fundamental core structures is not exclusive to chemical compounds extracted from the same natural source. Common and highly resembling molecular frames can be identified throughout various forms of life, such as different (and often distantly related) families of plants, corals, algae, as well as fungi and even bacteria.

Numerous molecules of life (steroids, terpenoids, alkaloids and fatty acids) were discovered to share common fundamental architectures that, we now believe, determine their pharmacological orientation and contribute to their activity. During the studies, the discovered common cores were designed in our laboratory, and further translated to the synthesis of a broad spectrum of complex molecules via sequence of controlled, simple and atom economy reactions. The invented methodology provides simplified and fast access to a wide variety of important classes of biologically active and structurally interesting molecules on a biologically compatible tests scale. Molecules thus built, are tested in a broad range of biological assays (measuring primary activities, efficacy, selectivity and cellular toxicity) in a rapid and efficient manner.

Offering a conceptually new perspective, it became possible to generate advanced scaffolds that unite different groups of natural molecules and "launch" the necessary type of pharmacological activity. Each of the new products is subjected to a biological evaluation study to reveal its potential therapeutic activity. Positive results drive the selective synthesis of the desired compound and its structural analogues utilizing simple synthetic techniques. Obviously, the developed type of retrosynthetic analysis allows for saving time and financial costs associated with studying the specificity of the pharmacological activity of the molecules.

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