Multiple Targets via Selective Transformations from a Common Molecular Unit
The presence of similar fundamental core structures is not exclusive to chemical compounds extracted from the same natural source. Common and highly resembling molecular frames can be identified throughout various forms of life, such as different (and often distantly related) families of plants, corals, algae, as well as fungi and even bacteria. Numerous molecules of life (steroids, terpenoids, alkaloids and fatty acids) were discovered to share common fundamental architectures that, we now believe, determine their pharmacological orientation and contribute to their activity.
During the studies, the discovered common cores were designed in our laboratory, and further translated to the synthesis of complex molecules via sequence of controlled, simple and atom economy reactions. The invented methodology provides simplified and fast access to a wide variety of important classes of biologically active and structurally interesting molecules on a biologically compatible tests scale. Molecules thus built, can now be tested in a broad range of biological assays (measuring primary activities, efficacy, selectivity and cellular toxicity) in a rapid and efficient manner. Offering conceptually new perspective, it became possible to generate advanced scaffolds that unite different groups of natural molecules and "launch" the necessary type of pharmacological activity. Once synthesised, each of the new products is subjected to a biological evaluation study, thus revealing its potential therapeutic activity. A positive result drive the selective synthesis of desired compound and its structural analogues (libraries) utilizing the simple synthetic techniques.
To understand the concepts and mechanisms which underlie the complexities of parallel synthesis of multiple targets via sequence of controlled, simple and atom economy reactions from a single common molecular unit. To provide simplified access to a wide variety of important classes of biologically active and structurally interesting molecules
To discover and identify novel active chemical compounds. To understand the ligand-host interactions by using both natural products and synthesis of bioactive natural products-like molecules.
Complete synthesis of cannabinoids and their unnatural analogues
We develop innovative and improved synthesis of a several common cannabinoids: THC, CBG, CBD, THCV, as well as a genuine derivatization of (-)-Δ9- THCV and CBG. We also create synthetic fusions between pharmacologically active market drugs and cannabinoid compounds aiming to discover a new synergetic activity of hybridized substances.